We should marvel how demons and various diseases are dispelled by the sign of the precious and lifegiving Cross, which all can make without cost or effort. Who can number the panegyrics composed in its honour? The holy fathers have handed down to us the inner significance of this sign, so that we can refute heretics and unbelievers. The two fingers and single hand with which it is made represent the Lord Jesus Christ crucified, and He is thereby acknowledged to exist in two-natures and one hypostasis or person. The use of the right hand betokens His infinite power and the fact that He sits at the right hand of the Father. That the sign begins with a downward movement from above signifies His descent to us from heaven. Again, the movement of the hand from the right side to the left drives away our enemies and declares that by His invincible power the Lord overcame the devil, who is on the left side, dark and lacking strength.
St. Peter of Damaskos